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Wynberg is an industrial township situated just outside the commercial node of Sandton, not far from Marlboro. Land use in the region varies from residential in the west and the south, to industrial and manufacturing areas in the northeast. There is a lot of industrial activity in the suburbs of Wynberg and Kew and although growth in these traditionally industrial areas is slowing down, an industrial corridor is taking shape along the eastern edge of the N3. Major roads in the region include the M1 motorway, sections of the N1 Western Bypass and the N3 Eastern Bypass, Louis Botha Avenue, Corlett Drive, Oxford Road and Rivonia Road. 

Wynberg was one of the first industrial areas to rise out of the unprecedented growth of the Sandton CBD and offers a large variety of commercial property and industrial factory and storage space. There is ample warehouse space to let in Wynberg and surrounds. Situated near the Sandton CBD, this industrial suburb and commercial node has good security and access-controlled gates, ample space for truck reticulation and conveniently located near the M1 highway. The department of Home Affairs has a branch located in Wynberg and the Sandton Traffic department is present in the nearby Marlboro area. Modderfontein (neighbouring Wynberg) is used by AECI for the manufacture of explosives with light manufacturing taking place in Wynberg. The vast Frankenwald site, owned by the University of the Witwatersrand, is ear-marked for mixed-use development.

Commercial space is relatively well priced in this area with A, B and C grade facilities generally renting for R45/m² gross excluding CID levies of course. Industrial parks like those in Wynberg are usually located on the edges of, or outside the main residential area of a city, and normally provided with good transportation access, including road and rail. Industrial parks are usually located close to transport facilities, especially where more than one transport mode coincide, including highways, railroads, airports.

Commercial Areas